Follow our journey.
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Lab view.
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Imaging.
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Microfluidics.
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Microfabrication.
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Curing.
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Cell engineering.
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Robotics.
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Fabrication.
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Histology.
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Instrumentation.
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Molecular biology.
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Spatial host-microbiome sequencing.
Nature Biotechnology. 2023 Nov 20.
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In silico tissue generation and power analysis for spatial omics
Nature Methods. 2023 March 2.
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Nanobody-tethered transposition allows for multifactorial chromatin profiling at single-cell resolution.
Nature Biotechnology. 2022 Dec 19.
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PySeq2500: An open source toolkit for repurposing HiSeq 2500 sequencing systems as versatile fluidics and imaging platforms.
Scientific Reports. 2022 Mar. 24.
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Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium.
Nature Communications Biology. 2022 February 11.
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Direct detection of RNA modifications and structure using single molecule nanopore sequencing.
Cell Genomics. 2022 Feb 9.
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SM-Omics is an automated platform for high-throughput spatial multi-omics.
Nature Communications. 2022 February 10.
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Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.
Nature Biotechnology. 2021 June 3.
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Integrated analysis of multimodal single-cell data.
Cell. 2021 May 31.
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Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.
Nature Biotechnology. 2021 Apr. 29.
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Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens.
Nature Genetics. 2021 Mar. 1
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High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange.
Nature Communications. 2020 Apr. 20.
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Comprehensive Integration of Single-Cell Data.
Cell. 2019 June 6.
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Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells.
Nature Methods. 2019 Apr 22.
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Somatic mutations and cell identity linked by Genotyping of Transcriptomes.
Nature. 2019 July 3.
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High-throughput magnetic particle washing in nanoliter droplets using serial injection and splitting.
Micro and Nano Systems Letters. 2018 June 21.
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YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
Proc Natl Acad Sci U S A. 2018 June 6.
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Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.
Nature Communications. 2018 Feb. 23.
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Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics.
Genome Biology. 2018 Dec. 19.
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High-definition spatial transcriptomics for in situ tissue profiling.
Nature Methods. 2019 Sept. 9.
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Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis.
Science. 2019 Apr. 5.
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Large-scale simultaneous measurement of epitopes and transcriptomes in single cells.
Nature Methods. 2017 July 31.
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Massive and parallel expression profiling using microarrayed single-cell sequencing.
Nature Communications. 2016 Oct. 14.
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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
Science. 2016 Jul. 1.